Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women

Mitchell, C.; Balkus, J.E.; McKernan-Mullin, J.; Cohn, S.E.; Luque, A.E.; Mwachari, C.; Cohen, C.R.; Coombs, R.; Frenkel, L.M.; Hitti, J.; Mitchell, C; Balkus, J.E; McKernan-Mullin, J; Cohn, S.E; Luque, A.E; Mwachari, C; Cohen, C.R; Coombs, R; Frenkel, L.M; Hitti, J

doi:10.1097/qai.0b013e318274577d

Home

>

Node

>

Subnode

Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women

Mitchell, C.; Balkus, J.E.; McKernan-Mullin, J.; Cohn, S.E.; Luque, A.E.; Mwachari, C.; Cohen, C.R.; Coombs, R.; Frenkel, L.M.; Hitti, J.

Journal of Acquired Immune Deficiency Syndromes 62(2): 143-148

2013

ISSN/ISBN: 1525-4135

PMID: 23018377

DOI: 10.1097/qai.0b013e318274577d

Document Number: 572547

Cervical shedding of HIV-1 DNA may influence HIV-1 sexual transmission. HIV-1 DNA was detected in 250 (80%) of 316 and 207 (79%) of 259 cervical cytobrush specimens from 56 US and 80 Kenyan women, respectively. Plasma HIV-1 RNA concentration was associated with increased HIV-1 DNA shedding among US and Kenyan women. Kenyan women had higher cervicovaginal concentrations of proinflammatory interleukins (IL)-1β, IL-6, IL-8, and anti-inflammatory secretory leukocyte protease inhibitor compared with US women (all P < 0.01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women.