The anti-inflammatory and antioxidants effects of micronized fenofibrate in patients with visceral obesity and dyslipidemia
Broncel, M.; Cieślak, D.; Koter-Michalak, M.; Duchnowicz, P.; Mackiewicz, K.; Chojnowska-Jezierska, J.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 20(119): 547-550
2006
ISSN/ISBN: 1426-9686 PMID: 16875159 Document Number: 598066
In recent studies it was observed the pleiotropic properties beyond hypolipemic effects of fenofibrate: anti-inflammatory, antioxidants effects, positive impact on glucose metabolism, thrombosis, fibrinolytic system endothelial dysfunction. To estimate the effects of 4-weeks therapy of micronized fenofibrate in dose 267 mg/d on C-reactive protein (CRP), fibrinogen, thiobarbituric acid reaction substances (TBARS) concentrations in isolated erythrocyte membranes and the activities of antioxidants enzymes such: catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) in erythrocytes in patients with visceral obesity and atherogenic dyslipidemia. The study comprised 55 patients (pts), including 20 healthy volunteers and 35 pts with visceral obesity and dyslipidemia (TG>180 mg/dl, HDL-C < 40 mg/dl for men, <50 mg/dl for women) treated with micronized fenofibrate (267 mg/d). Before and after 4 weeks of active treatment the following parameters were determined: lipids (by enzymatic method using BioMerieux tests), CRP (by immunoturbidimetric method), fibrinogen (by Clauss'a method), TBARS concentrations (by method of Stock and Dormandy), CAT (method of Bartosz et al.), GSH-Px (method of Rice-Evansa), SOD (method of Misra) activities. It was noticed significantly higher concentrations of CRP fibrinogen, TBARS and lower activities of CAT GSH-Px, SOD in patients with visceral obesity and atherogenic dyslipidemia than in the control group. The micronized fenofibrate caused a significant decrease in serum total cholesterol (by 15%), TG (by 38%), CRP (by 35%), fibrinogen (by 26%) and TBARS (by 33%) concentrations associated with a increase in CAT (by 35%), GSH-Px (by 63%), SOD (by 31%) activities. We conclude that micronized fenofibrate beyond hipolipemic efficacy demonstrates the antioxidative and anti-inflammatory properties in patients with visceral obesity and atherogenic dyslipidemia.