The immunological effectiveness and reactogenicity of the vaccine "HEP-A+B-in-VAC" against hepatitis a and B
Chuĭkova, K.I.; Gordetskaia, E.L.; Gorbunov, M.A.; Maĭdaniuk, A.G.; Pomytkina, M.I.
Voprosy Virusologii 51(1): 31-33
2006
ISSN/ISBN: 0507-4088 PMID: 16515040 Document Number: 597884
The paper presents the results of field clinical tests of the new Russian vaccine "HEP-A+B-in-VAC" against hepatitis A and B. The vaccine has been found to be safe and to have a weak reactogenicity. After completion of a course of vaccination, seroconversion occurred in 100% of the vaccinated, the high titers of anti-HAV and HBs being found in 90.9 and 72.7% of the volunteers, respectively. A comparative analysis demonstrated that the reactogenicity of the new vaccine was less and its immunogenicity was higher than those in monovaccines against hepatitis A and B when they were co-administered.
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