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Reactogenicity and immunological effectiveness study of a complex paratyphoid B antigen

Stepanova, L.K.; Belaia, I.A.; Sergeeva, N.S.; Rubtsov, I.V.; Ageeva, V.A.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 76-82

1978

ISSN/ISBN: 0372-9311
PMID: 106608
Document Number: 127682
Reactogenic property and immunological efficacy of the paratyphoid preparation containing a complex of O-, K- and H-antigens obtained by single-stage antigens extraction were studied in a limited group of volunteers (22 persons). The antigen gave no untoward reactions and proved to be safe when given orally in doses of 25 to 150 mg. Paratyphoid B antigen was characterized by a marked immunization activity and stimulated formation of specific paratyphoid O-, K- and H-agglutinins and antibodies of the IgA,- IgG,- and IgM-classes.

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