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Experimental study on anti-tumor effect of extractive from Celastrus orbiculatus in vivo

Zhang, J.; Xu, Y.-M.; Wang, W.-M.; Liu, Y.-Q.

Zhongguo Zhong Yao Za Zhi 31(18): 1514-1516

2006

ISSN/ISBN: 1001-5302
PMID: 17144469
Document Number: 596001
To study the anti-tumor activity of extractive from Celastrus orbiculatus in vivo. Mice bearing transplanted tumor S180 and Heps were used to study the effects of acetoacetate and n-butanol extractive from C. orbiculatus. The changes in serum contents of SOD and malondialdehyde (MDA) content were assayed. Acetoacetate and n-butanol extractive from C. orbiculatus significantly inhibited the growth of S180 and Heps tumor in mice. SOD content was obviously increased, MDA content obviously decreased in the serum after extractive treatment. Acetoacetate and n-butanol extractive from C. orbiculatus have anti-tumor effects and anti-oxidative capacity.

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