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Antitumor effect of hippurate. An experimental study using various mouse tumor strains

Spustová, V.; Oravec, C.

Neoplasma 36(3): 317-320

1989

ISSN/ISBN: 0028-2685
PMID: 2739810
Document Number: 617
Hippurate had antitumor effects both in vitro and in vivo by killing dose-dependently the cells derived from Skalsky lymphoma, Németh-Kellner lymphoma, L-asparaginase sensitive 6C3HED Gardner lymphoma, and LP-2 plasmacytoma. There was no significant difference between the effect of hippurate and its maternal compound benzoate. Hippurate administered intraperitoneally twice a day at a dose of 1 g/kg body weight significantly inhibited the growth of solid 6C3HED Gardner lymphoma even in the case that the treatment was started when the tumors reached a weight of over 400 mg. It was concluded that benzoates could be an important endogenous group of substances with antitumor effects.

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Antitumor effect of hippurate. An experimental study using various mouse tumor strains

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