A Nematode Nobel Prize: Caenorhabditis elegans
Savel, J.; Clostre, F.
Annales Pharmaceutiques Francaises 64(5): 291-307
2006
ISSN/ISBN: 0003-4509 PMID: 17095949 Document Number: 595356
The Nematode Caenorhabditis elegans (C. elegans) is an established model increasingly used for studying human disease pathogenesis. C. elegans models are based on the mutagenesis of human disease genes conserved in this Nematode or on the transgenesis with disease genes not conserved in C. elegans. Genetic examinations will give new insights on the cellular and molecular mechanisms that are altered in some neurodegenerative diseases like Duchenne's muscular dystrophy, Huntington's disease and Alzheimer's disease. C. elegans may be used for primary screening of new compounds that may be used as drugs in these diseases.