Effects of antidepressants in models of brain self-stimulation and place preference after prolong social isolation and alcoholization
Shabanov, P.D.; Roik, R.O.; Lebedev, A.A.; Strel'tsov, V.F.
Eksperimental'naia i Klinicheskaia Farmakologiia 69(4): 60-65
2006
ISSN/ISBN: 0869-2092 PMID: 16995442 Document Number: 595308
In rats rearing in social isolation since 17th day of life and treated with 5-15% ethanol solution within 3 months, the effects of antidepressants on self-stimulation of lateral hypothalamus and place preference were studied. The comparative study of seven antidepressants with different mechanism of action (fluoxetine, maprotiline, tianaptine, pyrazidol, sertraline, citalopram, mianserin) was shown that pyrazidol and tianeptine and in a less degree sertraline and citalopram possessed the significant antidepressant activity in the model of social isolation and maprotiline and tianeptine did in model of alcoholization. It is concluded that antidepressants studied activate the reinforcing properties of the brain, that is associated with the involvement of both the catecholamine and serotonin system, working reciprocally.