Effect of bromocryptin on the alcohol consumption and catecholamine level in the brain of rats undergoing long-term alcoholization
Stanishevskaia, A.V.; Kogan, B.M.; Khristoliubova, N.A.; Anokhina, I.P.
Farmakologiia i Toksikologiia 48(3): 88-91
1985
ISSN/ISBN: 0014-8318 PMID: 4040870 Document Number: 248973
It has been established in experiments on rats subjected to long-term alcoholization that chronic administration of bromocryptin in small doses (1 mg/kg) considerably minimizes ethanol consumption by animals. Reduction in alcoholic motivation correlates with normalization of the level of dopamine, decreased by chronic alcohol action in the rat hypothalamus and midbrain. The use of bromocryptin also prevents an increase in the dopamine content in the rat hypothalamus during alcohol withdrawal.