Effects of calcium antagonists on the cocaine- and methamphetamine-induced conditioned place preference
Suzuki, T.; Shiozaki, Y.; Masukawa, Y.; Misawa, M.
Arukoru Kenkyu to Yakubutsu Izon 27(1): 81-90
1992
ISSN/ISBN: 0389-4118 PMID: 1596245 Document Number: 398643
The effects of calcium antagonists (nifedipine, flunaridine and diltiazem) on the cocaine- and methamphetamine-induced place preference were examined. Calcium antagonists alone induced neither place preference nor place aversion. Nifedipine markedly antagonized and flunarizine and diltiazem reduced the cocaine-induced place preference. The methamphetamine-induced place preference was reduced by nifedipine and diltiazem, but not by flunarizine. These results suggest the possibility that the cocaine-induced place preference is strongly influenced by dihydropyridine sensitive calcium channels, whereas the methamphetamine-induced place preference is not.