Study on the role of hepatic first-pass elimination in the low oral bioavailability of scutellarin in rats
Hao, X.; Cheng, G.; Yu, J.E.; He, Y.; An, F.; Sun, J.; Cui, F.
Die Pharmazie 60(6): 477-478
2005
ISSN/ISBN: 0031-7144 PMID: 15997843 Document Number: 594320
In the present study, we compared the systemic exposure of scutellarin (a flavone glucuronide isolated from Erigeron breviscapus) following intraportal with intravenous administration to understand the contribution of presystemic hepatic elimination to the low oral bioavailability. Results showed that the hepatic first-pass elimination of scutellarin played an insignificant role in the presystemic elimination of orally administered scutellarin. Moreover, our results suggested that the site of first pass extraction was not the liver, but the gastrointestinal tract.