Age related changes of physical-chemical parameters of erythrocytes
Arabuli, M.B.; Khetsuriani, R.G.; Dalakishvili, I.M.; Tkhilava, n.G.; Sanikidze, T.V.
Georgian Medical News 129: 113-116
2005
ISSN/ISBN: 1512-0112 PMID: 16444048 Document Number: 593911
The aim of our study was to investigate age related changes of physical-chemical parameters of erythrocytes. It is known that insufficiency of erythrocytes antioxidant defence system in newborns is a keystone of peculiarities manifested in homeostasis among this group. The excess volume of reactive oxygen determines disorders related to the functioning of cation channels that are represented by decrease of K(+) ions, moderate hydration of erythrocytes and may cause accumulation of intraerythrocyte calcium. Excessive calcium may also cause activation of Ca(2+)-dependent erythrocytes' NOS and increase of nitric oxide content in newborns' erythrocytes. However, in spite of high NO content, the insufficiency of antioxidant system is conductive to intensive formation of methaemoglobin in newborns' blood. The other cause of intensive haemolysis of erythrocytes in this age group may be also the activation of Ca(2+)-dependent mechanism, which contributes to the exposition of phosphatidilserin on the surface of the erythrocyte's membrane and elimination of erythrocytes by macrophages. The increasing activity of antioxidant enzymes among aged persons seems to be a compensatory mechanism against excessively reactive oxygen in old age and this process ensures maintenance of intensity of hemolysis within the physiological frames.