Inclusion constant of beta-CD and paeonol measured by phase solubility method
Wu, X.-f.; Zheng, X.-k.; Yao, H.-j.; Fei, N.
Zhongguo Zhong Yao Za Zhi 30(7): 501-503
2005
ISSN/ISBN: 1001-5302 PMID: 16011091 Document Number: 592675
Measure the thermal stability and the forming constant of inclusion complex for paeonol with beta-CD, and investigate interaction between beta-CD and paeonol, The thermal stability investigated by using different thermal analysis. The forming constant was determined by using phase method. Comparing with melt temperature of paeonol, that of its inclusion complex increase about 220 degrees C. The solubility of paeonol increases with the increased concentration of beta-CD, the composing ratio and the inclusion constant of beta-CD-paeonol is respectively 1/1 and 27.42 mL x mg(-1). Inclusion constant is applied to research the stability of included drug in physiological condition.