Application of beta-cyclodextrin inclusion technique in new dosage form of angelica sinensis essential oil
Zhou, C.-x.; Zou, J.-k.; Zhao, Y.; Chen, Y.-z.
Zhongguo Zhong Yao Za Zhi 27(11): 832
2002
ISSN/ISBN: 1001-5302 PMID: 12776586 Document Number: 541674
To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex. GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound. The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same. The results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.