Structural changes of the retina and corpus vitreum in the model of proliferative vitreoretinopathy in alloxan diabetes
Logvinov, S.V.; Krivosheina, O.I.; Zapuskalov, I.V.; Varakuta, E.I.; Potapov, A.V.
Morfologiia 127(3): 34-37
2005
ISSN/ISBN: 1026-3543 PMID: 16381309 Document Number: 592004
The present study was conducted to determine the role of blood mononuclear cells in a morphogenesis of proliferative vitreoretinopathy (PVR) and to detect the peculiarities of PVR development in hyperglycemia. Experiments were performed in 75 mature male Wistar rats. In animals of group 1, the model of PVR was reproduced by injection of mononuclear cells into the corpus vitreum. In animals of group 2, alloxan diabetes was induced 6.5 weeks prior to intravitreal injection of mononuclear cells. The material obtained was studied using the methods of light and electron microscopy. Development of PVR by intravitreal injection of mononuclear cells in diabetic rats was found to be associated with more severe destructive and proliferative changes. Considering the integrative role of blood mononuclear cells in the intercellular networks, it is suggested that these cells are involved in the pathogenesis of PVR.