Do prothrombin time, transaminases, and platelet count predict the severity of fibrosis in viral liver diseases?
Mohamed, M.A.; Majda, E.; Mohamed, K.; Bechir, Z.; Sana, K.; Ehsène, B.B.; Samia, C.
La Tunisie Medicale 83(7): 400-403
2005
ISSN/ISBN: 0041-4131 PMID: 16220696 Document Number: 591273
The goal of our study is to assess the performance of a score combining 3 serological parameters (PT, platelets and transminases) in predictive hepatic fibrosis. The study involved 54 patients, 29 of which resulted in distributing them according to the score of Metavir into 2 groupes: Group A with mild fibrosis (F1,F2) and group B with severe fibrosis (F3,F4). PT, platelets and transminase values in serum were assessed for all patients. The total score of the 3 biological parameters combined, was significantly more elabled in the severe fibrosis group than in the mild fibrosis group (P = 0.01) but it was not of much importance in 30% of cases as it did not allow to classify the patients with certainty in group A or in group B. This score does not seem to grant exemption from needle liver biopsy, but it can be improved by the association of other direct markers of fibrosis.