Color reaction of chlorhexidine and proguanil with hypobromite
Görlitzer, K.; Huth, S.; Jones, P.G.
Die Pharmazie 60(4): 269-272
2005
ISSN/ISBN: 0031-7144 PMID: 15881606 Document Number: 590914
Colour reaction of chlorhexidine and proguanil with hypobromite The antimalarial agent proguanil reacts with hypobromite to yield the red coloured (E)-3-[(4-chlorophenyl)imino]-N-isopropyl-3H-1,2,4-triazol-5-amine (6B). The structure of 6B was proven by X-ray. The red colour obtained by the test for the disinfectant chlorhexidinedihydrochloride Ph. Eur. with hypobromite is probably attributable to a corresponding chromophore.