Exacerbation of psoriasis caused by malaria prophylaxis with chloroquine and proguanil
Damstra, R.J.; van Vloten, W.A.
Nederlands Tijdschrift Voor Geneeskunde 135(15): 671-673
1991
ISSN/ISBN: 0028-2162 PMID: 2038384 Document Number: 376344
Two patients with psoriasis vulgaris who travelled to endemic malaria areas developed erythroderma and generalized psoriasis guttata 3-4 weeks after starting prophylactic antimalarial medication with chloroquine/proguanil. The lesions resolved after 3 months of intensive treatment and discontinuation of the antimalarial drugs. The literature on these less known adverse effects of antimalarials in psoriatic patients is reviewed. Because of the severity of a malaria infection we advise psoriasis patients to have adequate malaria prophylaxis.