Exacerbation of psoriasis due to interferon-alpha treatment of chronic active hepatitis
Georgetson, M.J.; Yarze, J.C.; Lalos, A.T.; Webster, G.F.; Martin, P.
American Journal of Gastroenterology 88(10): 1756-1758
1993
ISSN/ISBN: 0002-9270 PMID: 8213720 Document Number: 414962
Interferon-alpha is an immune modulating drug which is indicated for the treatment of chronic viral hepatitis B and C. Several previous reports have suggested an association between treatment of patients with interferon-alpha and the development or exacerbation of autoimmune diseases. We report two patients with chronic viral hepatitis in whom treatment with interferon-alpha was associated with dramatic worsening of previously diagnosed psoriasis, necessitating discontinuation of the drug.