Efficacy of high dose interferon--alpha treatment of chronic hepatitis B
Techapaitoon, S.
Journal of the Medical Association of Thailand 82(11): 1118-1126
1999
ISSN/ISBN: 0125-2208 PMID: 10659547 Document Number: 6678
Fifteen consecutive Hepatitis B virus chronic hepatitis patients were treated with interferon alfa-2B 10 mu tiw for 5-6 months. All patients could tolerate the side effects without serious complications throughout the treatment period. Overall, 12 cases had normalization of ALT (80%), 7 cases had loss of HbeAg with appearance of anti-Hbe (58.33%) and 2 cases had loss of HbsAg with the presence of antiHBs (13.33%). The response usually associated with improvement in histology and decrease in viral load. These results seemed to be better than other studies with a lower dose. Further study with more patients should be done in the future.
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