Complete response of recurrent gastric cancer to chemotherapy with TS-1 and CPT-11--a case report
Morishita, Y.; Kasakura, Y.; Fujii, M.; Yamagata, M.; Kochi, M.; Sato, K.; Takayama, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 32(6): 847-849
2005
ISSN/ISBN: 0385-0684 PMID: 15984529 Document Number: 589879
A 58-year-old man with gastric cancer who had undergone distal gastrectomy on February 8, 2001 was revealed to have anorexia, and was diagnosed with a local recurrence in anastomosis by upper GI examination in August 2003. In September 2003, he was given combination chemotherapy with TS-1 50 mg/m2 (days 1-14) and CPT-11 80 mg/m2 (days 1, 8) every 3 weeks. A complete response (CR) was confirmed by endoscopy in December 2003. At present, he has been receiving chemotherapy with only TS-1 50 mg/m2 as a maintenance therapy and continuing CR. However, a trial of combination therapy with TS-1 plus CPT-11 is ongoing, and this combination chemotherapy may well achieve a high response rate. Because the adverse events of this chemotherapy have been mild and tolerable in some of our cases, this regimen is considered very useful.