Effect of testosterone concentration on the intensity of 5alpha-dihydrotestosterone and 17beta-oestradiol formation

Pechorskiĭ, A.V.; Mazurov, V.I.; Semiglazov, V.F.; Karpishchenko, A.I.; Udintsev, A.V.; Pechorskii, A.V; Mazurov, V.I; Semiglazov, V.F; Karpishchenko, A.I; Udintsev, A.V

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Effect of testosterone concentration on the intensity of 5alpha-dihydrotestosterone and 17beta-oestradiol formation

Pechorskiĭ, A.V.; Mazurov, V.I.; Semiglazov, V.F.; Karpishchenko, A.I.; Udintsev, A.V.

Tsitologiia 47(2): 172-174

2005

ISSN/ISBN: 0041-3771

PMID: 16706180

Document Number: 589393

The culture of human male foreskin fibroblasts was incubated with various concentrations of testosterone in the medium. It has been shown that the minimum formation of 17beta-oestradiol and 5alpha-dihydrotestosterone occurs at physiological testosterone concentrations. Any deviation of testosterone concentration, both up and down, was accompanied by an increase in the formation of 17beta-oestradiol and 5alpha-dihydrotestosterone.