Influence of estradiol benzoate on fluid reabsorption capacity of rat efferent ductuli
Zhang, Q.; Zhou, X.-H.; Zhang, X.-B.; Zhou, Q.-H.; Wang, D.-Z.; Chen, X.-C.
Zhonghua Nan Ke Xue 11(11): 806-809
2005
ISSN/ISBN: 1009-3591 PMID: 16333954 Document Number: 589105
To study the influence of estradiol benzoate (E2B) on the fluid reabsorption capacity of rat efferent ductuli. Newborn male Sprague-Dawley rats were injected subcutaneously with E2B (0.2 mg/5 g body weight), and the histological morphology of efferent ductulus, epithelial ultrastructure, and immunoexpression of AQP-1 were investigated on postnatal day 14, 21, 28, 42 and 56, respectively. Vehicle was given to the controls. After exposure to E2B, the lumina of the efferent ductuli dilated greatly (P < 0.05), and the epithelium height decreased significantly (P < 0.01), microvilli of nonciliated cells short and sparse, endocytic apparatus implicated in fluid reabsorption scarce, and with no AQP-1 expression. High dosage of E2 B neonatally administrated to rats damages the fluid reabsorption capacity of efferent ductuli.