Influence of uranyl nitrate upon tubular reabsorption and glomerular filtration in blood perfused isolated dog kidneys
Nizet, A.
Pflugers Archiv European Journal of Physiology 391(4): 296-300
1981
ISSN/ISBN: 0031-6768 PMID: 7312561 Document Number: 175643
The early changes in tubular reabsorption, glomerular filtration, blood flow and Na excretion brought about by uranyl nitrate were investigated in isolated, blood-perfused dog kidneys during water diuresis. No significant changes in urine volume were observed; the decrease in fluid reabsorption was counterbalanced quantitatively by a reduction in glomerular filtration rate; only a small diminution of renal blood flow was found. The balance between reabsorption and filtration was observed as well when angiotensin action or prostaglandin synthesis was inhibited. The intrarenal venous pressure rose, suggesting that an increase in proximal intratubular hydrostatic pressure caused the decrease in filtration. Tubular back-leak of fluid and back-diffusion, induced by the toxin, were excluded. The presence of natriuretic compounds in the urine was confirmed.