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Protection of puerarin on the cerebral injury in the rats with acute local ischemia

Pan, H-Ping.; Yang, J-Zhen.; Mo, X-Lan.; Li, L-Li.; Huang, Z-Lu.; Ye, J.; Huang, J.

Zhongguo Zhong Yao Za Zhi 30(6): 457-459

2005

ISSN/ISBN: 1001-5302
PMID: 15810455
Document Number: 586192
Objective: To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage was evaluated by staining with hematoxylin and eosin((HE). Result: The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P < 0.05). Similarly, the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats. Conclusion: Puerarin can prevent the neuron from damage induced by acute cerebral ischemia.

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