Development of immunopathology in patients with yersinia infection
Shestakova, I.V.; Iushchuk, N.D.; Andreev, I.V.; Shepeleva, G.K.; Popova, T.I.
Terapevticheskii Arkhiv 77(11): 7-10
2005
ISSN/ISBN: 0040-3660 PMID: 16404853 Document Number: 585834
To evaluate clinical significance of changes in IL-6 concentration and neopterin in peripheral blood of patients for prognosis of the course and outcome of yersinia infection (YI). Clinical examination and laboratory tests, 1-5-year follow-up were conducted in 68 patients with a cyclic, recurrent and lingering course of the disease. IL-6 and neopterin concentrations were measured in the course of the disease. Dynamic control over IL-6 concentrations in the blood of patients with yersinia infection provides information predicting the disease course and prognosis. Blood concentrations of neopterin are of help in prognostication of long-term outcomes of acute infection. Pathological syndromes forming in acute stage of yersinia infection are related to interleukin-dependent immunopathology.