Manufacturing and stability of copper-histidine solution for treatment of Menkes' Kinky Hair Syndrome
Hoppe-Tichy, T.; Nguyen, T.H.; Hentze, B.W.; Lorke, M.
Die Pharmazie 60(3): 205-207
2005
ISSN/ISBN: 0031-7144 PMID: 15801674 Document Number: 585403
Menkes' Kinky Hair Syndrom is a rare, X-linked recessive multisystemic lethal disorder of copper metabolism. Male infants who are affected usually die at the age of 2-3 years. If the disease is diagnosed early, patients profit from subcutaneously administered copper salts. We describe the preparation and stability of a copper-histidin solution. This solution has some advantages in terms of stability over the solutions described in earlier publications. This is a great advantage for the patients and their parents, because an ambulatory care or a home care of this patients is possible now.