Antidepressant amides from Piper laetispicum C. DC
Pan, S-li.; Xie, J.; Qian, F-gang.; Wang, J.; Shao, Y-ci.
Yao Xue Xue Bao 40(4): 355-357
2005
ISSN/ISBN: 0513-4870 PMID: 16011266 Document Number: 585386
A study was conducted to investigate the antidepressant constituents of Piper laetispicum. The compounds were enriched by column chromatography on silica gel. Structural determination of the pure compounds was based on extensive analyses of modern spectroscopic methods including MS, HR-MS, UV, IR, 1D- and 2D-NMR spectra. The mouse forced swimming test was used for chasing antidepressant activity. Three amides were isolated and identified as N-isobutyl-(3,4-methylendioxyphenyl)-2E,4E,9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E,4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E,4E-heptadienamide (III). Compound I is a new compound named as laetispicine. Compounds II and III were isolated for the first time as natural substance.