Amides of creatine: perspectives of neuroprotection
Vlasov, T.D.; Chefu, S.G.; Baĭsa, A.E.; Leko, M.V.; Burov, S.V.; Veselkina, O.S.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 97(7): 708-717
2011
ISSN/ISBN: 0869-8139 PMID: 21961295 Document Number: 651549
We evaluated the efficacy of derivatives of creatine and amino acids (CrAA) for decreasing cerebral injury in rats with transient middle cerebral artery occlusion (MCAO). Neuroprotective effects of amides of creatine and glycine (CrGlyOEt), phenylalanine (CrPheNH2), thyrosine (CrTyrNH2), and GABA (CrGABAOEt) were investigated. Brain injury was evaluated on day 2 after transient MCAO using a TTC staining of brain slices. Compared with the MCAO control group, all the CrAms showed decreased cerebral injury (p < 0.05). However CrPheNH2, CrTyrNH2, and CrGABAOEt were toxic after intravenous administration and investigated only after intraperitoneal injection. CrGlyOEt did not show any toxicity at dose of 1 mmol/kg. These data evidenced that creatinyl amides can represent promising candidates for the development of new drugs useful in brain ischemia treatment.