Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release
Sammartino, G.; Marenzi, G.; Tammaro, L.; Bolognese, A.; Calignano, A.; Costantino, U.; Califano, L.; Mastrangelo, F.; Tetè, S.; Vittoria, V.
International Journal of Immunopathology and Pharmacology 18(3 Suppl): 55-62
2005
ISSN/ISBN: 0394-6320 PMID: 16848988 Document Number: 585355
In this paper we present the formulation, preparation and characterization of new polymeric composite materials containing a nano-hybrid to be used for the controlled molecular delivery of an anti-inflammatory molecule, Diclofenac. The nano-hybrid consists of a layer of double hydroxide of an Mg-Al hydrotalcite type, in which we replaced the chloride anions present in the host galleries with Diclofenac anions by a simple ion-exchange reaction. Different amounts of the hybrid material were incorporated in polycaprolactone and processed as films of 0.15 mm thickness. The composite materials were analyzed by X-ray diffractometry, thermogravimetry and for their mechanical properties, and showed properties even better than those for the pristine polymer. The release process of the anti-inflammatory molecules was very interesting and promising for tuneable drug delivery. It consists of two stages: a first stage, very rapid as a burst in which a small fraction of the drug is released, and of a second stage that is much slower, extending for longer and longer periods. The parameters influencing the drug release were individuated and discussed.