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Cytostatic effects of bifolar and chlofiden. Effect on protein synthesis and cell cycle

Sharykina, N.I.; Bukhtiarova, T.A.; Kudriavtseva, I.G.; Pavlovskaia, G.P.

Ukrains'kyi Biokhimichnyi Zhurnal 76(1): 123-129

2004

ISSN/ISBN: 0372-3909
PMID: 15909427
Document Number: 582453
Study of influence of new antitumor preparations bifolar and chlofiden on rat liver protein biosynthesis in vivo and on sarcoma-45 in vitro was carried out using labeled precursor 3H-leucine. It was shown that the preparations inhibited protein synthesis in normal and malignant tissues. Mitotic cycle and its phases were investigated with 3H-tymedin. It was established that bifolar influenced all the phases of mitotic cycle and the sensitive phases of the mitosis itself, which are connected with the redistribution of genetic material.

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