Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries
Machado, E.Stankiewicz.; Krauss, M.R.; Megazzini, K.; Coutinho, C.Milani.; Kreitchmann, R.; Melo, V.Hugo.; Pilotto, Jé.Henrique.; Ceriotto, M.; Hofer, C.B.; Siberry, G.K.; Watts, D.Heather.; Losso, M.H.; Foradori, I.; Hakim, A.; Stankievich, E.; Ivalo, S.; Pinto, J.A.; Melo, V.H.; Kakehasi, F.; Andrade, B.M.; Sperhacke, R.Dea.; Golin, N.; Costamilan, Sílvia.Mariani.; Pilotto, J.; Fernandes, L.Eduardo.; Falco, G.; Sperhacke, R.Dea.; Santos, B.Riegel.; Alves Lira, R.de.Cassia.; Sperhacke, R.Dea.
Journal of Infection 68(6): 572-580
2014
ISSN/ISBN: 0163-4453 PMID: 24462561 DOI: 10.1016/j.jinf.2013.12.018Document Number: 582267
To evaluate the incidence of and risk factors for hypertensive disorders in a cohort of HIV-infected pregnant women. Hypertensive disorders (HD) including preeclampsia/eclampsia (PE/E) and pregnancy induced hypertension, and risk factors were evaluated in a cohort of HIV-infected pregnant women from Latin America and the Caribbean enrolled between 2002 and 2009. Only pregnant women enrolled for the first time in the study and delivered at ≥20 weeks gestation were analyzed. HD were diagnosed in 73 (4.8%, 95% CI: 3.8%-6.0%) of 1513 patients; 35 (47.9%) had PE/E. HD was significantly increased among women with a gestational age-adjusted body mass index (gBMI) ≥25 kg/m(2) (OR = 3.1; 95% CI: 1.9-5.0), hemoglobin (Hg) ≥11 g/dL at delivery (OR = 2.1; 95% CI: 1.2-3.6) and age ≥35 years (OR = 1.8; 95% CI: 1.1-3.2). PE/E was increased among women with a gBMI ≥25 kg/m(2) (OR = 3.0; 95% CI: 1.5-6.0) and Hg ≥11 g/dL at delivery (OR = 2.8; 95% CI: 1.2-6.5). A previous history of PE/E increased the risk of PE/E 6.7 fold (95% CI: 1.8-25.5). HAART before conception was associated with PE/E (OR = 2.3; 95% CI: 1.1-4.9). HIV-infected women, with a previous history of PE/E, a gBMI ≥25 kg/m(2), Hg at delivery ≥11 g/dL and in use of HAART before conception are at an increased risk of developing PE/E during pregnancy.
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