Studies on DNA damage in workers with long-term exposure to lower concentration of carbon disulfide
Chen, X-qing.; Tan, X-dong.
Zhonghua Yu Fang Yi Xue Za Zhi 38(1): 36-38
2004
ISSN/ISBN: 0253-9624 PMID: 14989902 Document Number: 579191
Objective DNA damage in human buccal cells of workers occupationally long-term exposed to carbon disulfide ( CS2) was monitored with comet assay. Methods Ninety workers exposed to CS2 were randomly selected as exposure group from a large-scale chemical fiber manufacturer in Hubei and 81 workers not exposed to CS2 as control group. DNA damage in their buccal cells was detected with comet assay. Results Rate of DNA tail was 0.51% in exposure group, significantly higher than that in control group (0.23%), with very statistical significance. Rate of DNA tail was 0.50% in male exposure group and 0.56% in exposure group with short length of employment, significantly higher than that in control group (0.08% and 0.25%, respectively). Multivariate unconditional logistic regression anlaysis showed that possibility of DNA damage was significantly higher in exposure group than that in control group (P 0.05). Conclusion Long-term exposure to lower concentration of carbon disulfide could cause certain damage to human buccal cell DNA.