Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population
Fu, L-qing.; Huang, F.; Wu, D-zheng.; Guo, J-hua.
Yao Xue Xue Bao 39(3): 161-163
2004
ISSN/ISBN: 0513-4870 PMID: 15171646 Document Number: 578288
Aim: To assess the effect of gender on genetic polymorphism of cytochrome CYP2C19 in Chinese population. Methods: The genetic polymorphism of 140 healthy Chinese were analysed by PCR-RFLP (restriction fragment length polymorphism). Results: Of 52 genotyped male subjects, 23 (44.23%) were homozygous for wildtype (wt/wt), 6 (11.54%) were homozygous for CYP2C19 m1 (m1/m1), and 23 (44.23%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); and among the 88 genotyped female subjects, 31 (35.23 %) were homozygous for wildtype (wt/wt) , 13 (14. 82%) were homozygous for CYP2C19 m1 (m1/m1) , and 44 (50.0%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); no homozygous genotype for CYP2C19 m2 (m2/m2) was found in the study. Conclusion: There is no statistical difference in ocurance of wt/wt and m1/m1 between in male and in female, so gender have no significant effect on genetic polymorphism of cytochrome CYP2C19.