Genetic polymorphism of antithrombin IIi in five Chinese populations
Gou, Q.; Wu, J.; Hou, Y.; Xu, Y.; Jin, Z.; Wu, M.
Hua Xi Yi Ke da Xue Xue Bao 27(2): 146-150
1996
ISSN/ISBN: 0257-7712 PMID: 9389029 Document Number: 458451
The genetic polymorphisms of antithrombin III (AT III) in 5 Chinese populations were studied by isoelectric focusing on polyacrylamide gels followed by immunoblotting. The products of two alleles at the antithrombin III locus together with 1 AT III anodic variant and 3 cathode variants were observed. The results revealed that the predominant allele of AT III blood group system in Chinese populations was AT III *1, with frequencies between 0.9773-0.9850. Frequencies of AT III *2 ranged from 0.0091 to 0.0169. These results indicate that the polymorphic information content of AT III blood group system in Chinese populations is limited.