Polymorphism of vitamin D receptor and lead poisoning genetic polymorphism in Han, Uygur and Kazak child in China
Zhao, J.; Chen, Y.; Liu, J.; Tian, W.
Wei Sheng Yan Jiu 37(6): 697-699
2008
ISSN/ISBN: 1000-8020 PMID: 19239005 Document Number: 627945
To explore the relationship between the polymorphism of vitamin D receptor (VDR) and genetic polymorphism in Han, uygur and Kazak child in China. The VDR genotyping was determined by PCR-RFLP in 469 Han, 443 Uygur and 516 Kazak child from Xinjiang province. The correlation between the polymorphism of VDR and blood lead levels were explored. The frequencies of the allele BsmIB and BsmIb in Han child were 6% and 94%, and in Uygur were 18% and 82%, in Kazak were 43% and 57% respectively. Statistic correlation between the distribution of VDR-BsmI alleles and the blood lead level was found in Han and Uygur. The genetic susceptibility of VDR polymorphism to lead toxicity may exhibit in a lead dose-dependent manner.