Association between genetic polymorphism of the six-transmembrane protein of prostate 2 and obesity in Uygur
Han, R-mei.; Zhang, X-yang.; Yan, Z-tao.; Zhang, J-hong.; Guo, Y-ying.; Wang, H-mei.; Zhou, L.; Li, N-fang.
Zhonghua Xin Xue Guan Bing Za Zhi 40(12): 1024-1029
2012
ISSN/ISBN: 0253-3758 PMID: 23363718 Document Number: 656477
To investigate the association between genetic variations of the six transmembrane protein of prostate 2 (STAMP2) and obesity in Xinjiang Uygur population. A total of 2332 Uygur subjects (1455 obesity and 877 non-obesity control subjects) were included in this case-control study based on epidemiological survey. Genetic variations of STAMP2 gene functional region were sequenced. The representative variations selected were genotyped by TaqMan-PCR method. Twenty genetic variations, including 14 novel variations, were identified. The genotype distributions of the control group and obesity group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequency of AA of rs1981529 (67.6% vs. 62.8%, P < 0.05) and the frequency of G-A-G haplotype (62.4% vs. 58.9%, P < 0.05) in obesity group were significantly higher than that in controls while the frequency of A-G-G haplotype was significantly lower in the obesity patients than that in the control group (17% vs. 20%, P < 0.05). After adjusting age, sex, smoking and drinking, logistic regression analysis showed that the AA genotype of rs1981529 (OR: 1.276, 95%CI: 1.049 - 1.552; P < 0.05) and the G-A-G haplotype (OR: 1.356, 95%CI: 1.007 - 1.862, P < 0.05) were the independent risk factors for obesity in this cohort. The AA genotype of rs1981529 and G-A-G haplotype are associated with obesity in Uygur population of Xinjiang.