Spasmolytic activity of 4-methylumbelliferone on Oddi's sphincter. Studies on the mode of action of the drug
Fontaine, L.; Grand, M.; Molho, D.; Boschetti, E.
Therapie 23(1): 63-74
1968
ISSN/ISBN: 0040-5957 PMID: 5671531 Document Number: 5769
The authors describe methyl-4-ombelliferone choleretic properties and precise the drug effect on cholecyst. Methyl-4-ombelliferone is not a cholagogue drug, and presents a selective oddian spasmolytic effect, observed on guineα-pig and dog : product balances its weck papa verinic potency by a high biliary concentration, duplicated by an entero-hepatic cycle, that may explain an in part local action.
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