Effects of pinaverium bromide on Oddi's sphincter
DiSomma, C.; Reboa, G.; Patrone, M.G.; Mortola, G.P.; Sala, G.; Ciampini, M.
Clinical Therapeutics 9(1): 119-122
1986
ISSN/ISBN: 0149-2918 PMID: 3815457 Document Number: 283981
Twelve to 15 days after cholecystectomy, endocholedochal pressure was measured in ten patients before and one hour after oral administration of 15 mg of pinaverium bromide (six patients) or placebo. The mean endocholedochal pressure was 7.1 +/- 0.25 mmHg before and 3.1 +/- 0.2 mmHg after pinaverium (P less than 0.01), and 7.0 +/- 0.2 and 6.8 +/- 1.2 mmHg in the placebo-treated patients. The results suggest that pinaverium bromide has a specific effect on the common bile duct and probably on Oddi's sphincter.