Some pathophysiological mechanisms of muscular tone impairment
Bogdanova, L.P.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 19-21
2004
ISSN/ISBN: 0031-2991 PMID: 15568498 Document Number: 575595
Pathophysiological mechanisms of the muscular tone was studied clinicoelectrophysiologically (the method of stimulating electromyography with evoked H-reflex) in 130 healthy subjects and 63 patients with dystonia musculorum deformans (23 patients of the latter were examined before and after intake of a therapeutic dose of L-DOPA). It was found that patients with impaired muscular tone have low activity of spinal motoneurons on both sides of the body especially the activity of phasic motoneurons and on the right side of the body. L-DOPA activates motoneurons, higher activation seen for the phasic motoneurons and on the right side of the body.