Mechanisms of small Intestine Motor Disorders during Endotoxemia and Pathophysiological Rationale for the use of Tributyrine as Anti-Inflammatory and Prokinetic Pharmaconutrient
Tropskaya, N.S.; Kislyakova, E.A.; Popova, T.S.
Anesteziologiia i Reanimatologiia 61(1): 43-47
2016
ISSN/ISBN: 0201-7563 PMID: 27192855 Document Number: 688580
Studying the mechanisms of the small intestine motor function disorders during endotoxemia and searching ways to mitigate them remain relevant. The article discusses the role of inflammatory mediators, in particular nitric oxide as a key factor in the generation of inflammatory response and brake the main neurotransmitter in the gut in the pathogenesis of the small intestine motor disorders during endotoxemia. Also discusses anti-inflammatory cholinergic path, which is realized with the participation of the autonomic nervous system. Possible mechanisms by which tributyrinte as a component of nutritional support creates a multiplier effect in arresting the inflammatory response and normalization of intestinal motility are suggested.