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Serotonin regulation of motor function of the small intestine

Lychkova, A.E.

Eksperimental'naia i Klinicheskaia Gastroenterologiia 3: 130-135

2011

ISSN/ISBN: 1682-8658
PMID: 21695962
Document Number: 648643
The review described serotonergic regulation of motor function of the small intestine. Motor neurons of the enteric nervous system and cells--pacemakers (cells of Cajal) play an important role in the regulation of motor activity of the small intestine. Activated serotonin receptors expressed by neuronal and effector cells initiate the phase II and III of the migrating motor complex (MMC), changes the duration of the cycle and frequency of MMC. Serotonin, acting on 5-HT(2B) -, 5-HT(3) - and 5-HT(4)-receptors expressed by the Cajal cell, regulate the frequency of slow waves and amplitude of electromotor activity of the small intestine.

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