Myocardial ischemic preconditioning: pathophysiological mechanisms and prospects of clinical application (a literature review)
Petrishchev, N.N.; Shliakhto, E.V.; Vlasov, T.D.; Galagudza, M.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 87(5): 688-705
2001
ISSN/ISBN: 0869-8139 PMID: 11452804 Document Number: 527976
Ischemic preconditioning (IPC, i.e. increase in the organ resistance to a prolonged ischemia which occurs after a brief ischemic challenge) seems to be one of the most powerful endogenous cardioprotective mechanisms known to date. Current data regarding molecular mechanisms of early (classic) IPC as well as the second window of protection are reviewed in the context of the concept of sequential three-staged development of protective effect. Based on original and published data, possible mechanisms of remote IPC are considered. The review comprises current ideas of existence of the IPC clinical correlates and its use in clinic.