Ultrasound-induced myocardial preconditioning: analysis of its effectiveness and mechanisms
Galagudza, M.M.; Shmonin, A.A.; Mishchenko, K.A.; Vlasov, T.D.; Petrishchev, N.N.
Biofizika 53(4): 691-696
2008
ISSN/ISBN: 0006-3029 PMID: 18819289 Document Number: 621568
It has been shown that exposure of the isolated rat heart perfused according to Langendorff to therapeutic ultrasound (210 kHz and 0.5-1.5 W/cm2 ) induces a cardioprotective response similar to ischemic preconditioning. This reduces the infarct size and improves the postischemic systolic and diastolic function. The ATP-sensitive K+ channel blocker glybenclamide abolished the protection afforded by ultrasound; in contrast, the free radical scavenger N-2-MPG did not influence the ultrasound-induced cardioprotective response.