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Platelet aggregation. I. Regulation by cyclic AMP and prostaglandin E1

Marquis, N.R.; Vigdahl, R.L.; Tavormina, P.A.

Biochemical and Biophysical Research Communications 36(6): 965-972

1969

ISSN/ISBN: 0006-291X
PMID: 4310150
DOI: 10.1016/0006-291x(69)90298-8
Document Number: 575358
Platelet aggregation plays a major role in thrombogenesis. This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate. It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation. This study showed that prostaglandin E1 (PGE1) also inhibits platelet aggregation and stimulates cyclic AMP synthesis by stimulation of adenyl cyclose. Caffeine, on the other hand, inhibits platelet phosphodiesterase, and increases cyclic AMP levels. PGA1 and PGF1 alpha can also inhibit platelet aggregation but only at very high concentrations.

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