The pharmacokinetics of cotrimoxazole sulphonamide in malnourished (marasmic) infants
Bravo, I.G.; Bravo, M.E.; Plate, G.; Merlez, J.; Arancibia, A.
Pediatric Pharmacology 4(3): 167-176
1984
ISSN/ISBN: 0270-322X PMID: 6436778 Document Number: 575
The phamacokinetics of trimethoprim-sulfamethoxazole was examined in 7 malnourished (marasmic) infants receiving cotrimoxazole (CMZ) for treatment of urinary tract infection. Comparisons were made with the SMZ and 100 mg SMZ, 5 ml), patients receiving 22 mg SMZ/kg body weight. Capillary blood samples, 0.05 ml were taken at prescribed intervals. Elimination half-life of SMZ in the marasmic infants was prolonged, 9.6 vs. 4.9 h, in their eutrophic counterparts. In addition, greater area under the curve (AUC), 573 vs. 328 .mu.g/ml per h, was noted in the malnourished group. This disparity may be due to differences in body fluid distribution between the 2 groups.
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