Assessment of HIV-1 patient recruitability in the Republic of Guinea-Bissau using African versus North American hematology and biochemistry reference intervals
Gómez Román, V.Raúl.; Jensen, S.Skov.; Leo-Hansen, C.; Jensen, K.Jarlov.; Janitzek, C.Mikkel.; Rodrigues, C.Medina.; Jespersen, S.; Katzenstein, T.Lea.; Té, D.da.Silva.; Fomsgaard, A.
Clinical and vaccine immunology CVI 19(8): 1322-1325
2012
ISSN/ISBN: 1556-679X PMID: 22675154 DOI: 10.1128/cvi.00170-12Document Number: 573235
Hematology and biochemistry reference intervals have been derived from healthy, HIV-negative populations to guide clinical trials worldwide. However, it is less clear how such values may be applied to clinical trials involving HIV-infected individuals. We show that contradictory interpretations about patient recruitability are reached when applying African versus North American reference intervals to an HIV-1 cohort in Guinea-Bissau. These observations underscore the need to question non-African guidelines in the context of HIV intervention clinical trials in Africa.