Safety of flurbiprofen in subjects with G-6-PD deficiency. in vivo and in vitro results
Passiu, G.; Mela, Q.; Perpignano, G.; Frigerio, R.; Cacace, E.
International Journal of Clinical Pharmacology Research 4(2): 137-139
1984
ISSN/ISBN: 0251-1649 PMID: 6469439 Document Number: 5726
The safety of flurbiprofen, a new non-steroidal anti-inflammatory drug was tested in individuals with G-6-PD deficiency. The study was carried out in vitro evaluating the erythrocyte levels of reduced glutathione under basal conditions and after incubation with the drug or acetylphenyl-hydrazine. In the red cells marked with 51Cr, survival was evaluated in vivo before and during flurbiprofen administration. The study shows that flurbiprofen has no oxidating activity in carriers of the G-6-PD Mediterranean variant.
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