Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines
Tomasi, S.; Lohézic-Le Dévéhat, F.; Sauleau, P.; Bézivin, C.; Boustie, J.
Die Pharmazie 59(4): 290-293
2004
ISSN/ISBN: 0031-7144 PMID: 15125575 Document Number: 569283
Crude methanol extracts of 58 mushroom species were screened for their cytotoxic activities against 2 murine cancer cell lines, L1210 and 3LL, using the tetrazolium assay. A majority of the extracts (74%) exhibited IC50>100 micro g/ml against both cell lines. The most marked activity against 1 of the cell lines was noted for 9 species (14% of the tested species). While Amanitales and Russulales species evaluated were not active, Polyporales and Boletales gave better results. Four species exhibited significant cytotoxic activities (IC50<=20 micro g/ml) against at least 1 of the 2 murine cancer cell lines (Ganoderma lucidum, Meripilus giganteus, Suillus granulatus and S. luteus). S. luteus had never been investigated for its cytotoxic compounds before.