Models of inter-group difference of the homeostasis system in patients with artificial heart valves and the set of laboratory parameters
Vavilova, T.V.; Razorenov, G.I.; Kadinskaia, M.I.; Sirotkina, O.V.; Pchelina, S.N.; émanuél', V.L.; Orlovskiĭ, P.I.; Gritsaenko, V.V.
Klinicheskaia Laboratornaia Diagnostika 2004(10): 41-44
2004
ISSN/ISBN: 0869-2084 PMID: 15584400 Document Number: 568119
Patients with artificial heart valves (AHV) belong to a unique multi-component model of the homeostasis system presenting an interaction of activated coagulation processes and pharmacological effects, on the one hand, and genetic peculiarities functioning homeostatic mechanisms, on the other hand. The described method was evaluated on the basis of multi-factor mathematic analysis by information-metry. The data obtained provided for isolating the most information-dense laboratory indices and some genetic polymorphisms describing the shaping of continuous intravascular coagulation of stage III in AHV patients. The clinicians and laboratory experts are offered a practical instrument for the diagnosis (prognostication) of the above condition. It was proven as necessary to examine (by the morphofunctional method) the intravascular activation of platelets and to determine the D-dimer in the remote period after prosthesis of heart valves.